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SGrade/USMLE Step 1/Cardiovascular System

Step 1 · 25 questions

Cardiovascular System Practice Questions

Coronary territories, pressure–volume loops, murmurs, ECG, congenital heart disease, HF, shock, endocarditis, arrhythmia drugs, and biomarkers — NBME-style integration.

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Sample questions

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Question 1Foundation

A 10-year-old boy is brought to the clinic for a routine check-up. On cardiac auscultation, a loud, holosystolic murmur is heard best at the left lower sternal border, radiating to the right sternal border. Which of the following is the most likely cause of this murmur?

AAortic stenosis
BMitral regurgitation
CVentricular septal defect
DPulmonic stenosis

Examiner's Design Intent

To test the precise knowledge of cardiac murmur characteristics, specifically differentiating between various systolic murmurs based on timing, location, and radiation, a high-yield clinical reasoning skill for Step 1.

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Question 2Foundation

A newborn presents with cyanosis and a single S2 on auscultation. Echocardiography reveals a single great artery arising from the right ventricle and overriding a ventricular septal defect, with right ventricular outflow tract obstruction. Which congenital heart disease is most consistent with these findings?

ATransposition of the great arteries
BTetralogy of Fallot
CTruncus arteriosus
DTotal anomalous pulmonary venous return

Examiner's Design Intent

The NBME designed this question to test a student's ability to precisely differentiate between various cyanotic congenital heart diseases based on specific echocardiographic findings and classic clinical signs (cyanosis,

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Question 3Foundation

A 65-year-old man presents with substernal chest pain radiating to his left arm. An electrocardiogram (ECG) shows ST-segment elevation in leads II, III, and aVF. Which coronary artery is most likely occluded?

ALeft anterior descending artery
BRight coronary artery
CCircumflex artery
DLeft main coronary artery

Examiner's Design Intent

The NBME designed this question to assess a student's foundational knowledge of ECG lead localization for myocardial infarction and the corresponding coronary artery anatomy, a critical skill for clinical diagnosis and r

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+ 22 more Cardiovascular System questions in this set

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More Step 1 topics

Physiology — Core ConceptsPulmonary SystemRenal SystemEndocrine SystemAnatomy — Core ConceptsReproductive System & Embryology
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