SGrade/USMLE Step 1/Reproductive System & Embryology
Reproductive System & Embryology Practice Questions
Early embryology, pharyngeal arches, chromosomal disorders, ovarian and uterine pathology, cervical cancer and STIs, male GU disease, and pregnancy complications.
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A 16-year-old male presents to his physician due to delayed puberty and concerns about infertility. Physical examination reveals tall stature, gynecomastia, small testes, and scant facial hair. Laboratory studies show elevated follicle-stimulating hormone (FSH) and luteinizing hormone (LH), with low serum testosterone. Karyotype analysis is ordered. Which of the following is the most likely chromosomal abnormality?
Examiner's Design Intent
The NBME designed this question to test the student's ability to recognize the classic, high-yield clinical presentation of Klinefelter syndrome, differentiate it from other sex chromosome abnormalities, and link it to i…
A 32-year-old woman undergoes a routine Papanicolaou (Pap) test. The results indicate high-grade squamous intraepithelial lesion (HSIL). A subsequent colposcopy with biopsy confirms cervical intraepithelial neoplasia grade 3 (CIN 3). This condition is most strongly associated with chronic infection by which of the following pathogens?
Examiner's Design Intent
To test the foundational knowledge of the primary etiologic agent for cervical intraepithelial neoplasia and cervical cancer, and to differentiate it from other common STIs. It assesses the ability to link a specific pat…
A 28-year-old primigravid woman presents for her 20-week anatomy scan. The ultrasound reveals an open neural tube defect in the lumbosacral region, along with a Chiari II malformation. Amniocentesis shows elevated alpha-fetoprotein and acetylcholinesterase. Supplementation with which of the following during the periconceptional period could have most likely prevented this condition?
Examiner's Design Intent
The NBME designed this question to test a high-yield, foundational concept in preventive medicine and embryology: the specific nutritional intervention for a common and serious congenital anomaly. It assesses direct reca…
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