SGrade/USMLE Step 1/Endocrine System
Endocrine System Practice Questions
Pituitary masses, thyroid disorders and cancer, Cushing and hyperaldosteronism, pheochromocytoma, adrenal insufficiency, DM complications, calcium disorders, MEN, SIADH vs DI.
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A 62-year-old woman presents with bone pain and a recent fracture after a minor fall. Laboratory tests show elevated serum calcium, decreased serum phosphate, and elevated parathyroid hormone (PTH) levels. Which of the following is the most likely underlying cause of her hypercalcemia?
Examiner's Design Intent
The NBME designed this question to test a student's ability to integrate multiple laboratory findings (calcium, phosphate, PTH) with a clinical presentation (bone pain, fracture) to diagnose a common endocrine disorder. …
A 25-year-old woman with a history of type 1 diabetes mellitus presents to the emergency department with nausea, vomiting, abdominal pain, and profound weakness. Her blood pressure is 85/50 mmHg. Laboratory tests show hyponatremia, hyperkalemia, and hypoglycemia. Her plasma ACTH is elevated, and cortisol is very low. Which of the following is the most appropriate immediate treatment?
Examiner's Design Intent
The NBME designed this question to assess a student's ability to recognize a life-threatening endocrine emergency (adrenal crisis) based on a constellation of symptoms, vital signs, and laboratory findings, and then to i…
A 35-year-old woman presents with anxiety, heat intolerance, weight loss despite increased appetite, and palpitations. Physical examination reveals a diffuse goiter and exophthalmos. Her TSH is undetectable, and free T4 is elevated. Which of the following is the most likely underlying mechanism of her condition?
Examiner's Design Intent
The NBME designed this question to test a student's ability to recognize the classic clinical and laboratory presentation of Graves' disease and identify its specific underlying autoimmune mechanism, differentiating it f…
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