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SGrade/USMLE Step 1/Virology

Step 1 · 25 questions

Virology Practice Questions

Herpesviridae, HPV, parvo, influenza and paramyxo, picornaviruses, HIV lifecycle and OIs, arboviruses, hemorrhagic fevers, coronaviruses, and ART classes.

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Sample questions

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Question 1Foundation

A 10-month-old infant presents with a 3-day history of high fever (up to 40°C) which resolved spontaneously this morning. Shortly after the fever broke, a maculopapular rash appeared on his trunk and neck, sparing the face. The infant appears otherwise well and active. Physical examination reveals no other significant findings apart from the rash. Which of the following viruses is the most likely causative agent?

AVaricella-zoster virus (VZV).
BParvovirus B19.
CHuman herpesvirus 6 (HHV-6).
DMeasles virus.

Examiner's Design Intent

The NBME designed this question to test a student's precise knowledge of the classic clinical presentation of roseola infantum and their ability to differentiate it from other common childhood viral exanthems based on sp

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Question 2Foundation

An 82-year-old man presents with a painful, blistering rash distributed in a band-like pattern on the left side of his chest, stopping abruptly at the midline. He had chickenpox as a child. Physical examination reveals vesicles and crusted lesions following the T4 dermatome. Which of the following best describes the underlying mechanism for this patient's current condition?

APrimary infection with a novel strain of herpes simplex virus.
BReactivation of latent varicella-zoster virus from dorsal root ganglia.
CAn allergic contact dermatitis triggered by environmental exposure.
DA localized bacterial skin infection with blistering.

Examiner's Design Intent

The NBME designed this question to assess a student's ability to recognize the classic clinical presentation of herpes zoster (shingles) and understand its underlying viral pathogenesis, specifically VZV reactivation fro

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Question 3Foundation

A 24-year-old man presents to the clinic with recurrent painful vesicular lesions on his lips. He states these outbreaks typically occur during periods of stress. Physical examination reveals clusters of vesicles on an erythematous base at the vermillion border of the upper lip. The lesions are consistent with herpes labialis. Which of the following best describes the mechanism of action of the most appropriate antiviral medication for this condition?

AInhibits viral DNA polymerase after phosphorylation by viral thymidine kinase.
BBlocks viral RNA-dependent RNA polymerase activity.
CPrevents viral uncoating by interfering with M2 protein.
DDisrupts the assembly of viral particles by targeting protease enzymes.

Examiner's Design Intent

The NBME designed this question to assess a student's precise knowledge of the mechanism of action of a common, high-yield antiviral drug (acyclovir) for a frequently encountered clinical condition (herpes labialis). It

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+ 22 more Virology questions in this set

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More Step 1 topics

Physiology — Core ConceptsCardiovascular SystemPulmonary SystemRenal SystemEndocrine SystemAnatomy — Core Concepts
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