SGrade/USMLE Step 1/Virology
Herpesviridae, HPV, parvo, influenza and paramyxo, picornaviruses, HIV lifecycle and OIs, arboviruses, hemorrhagic fevers, coronaviruses, and ART classes.
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A 10-month-old infant presents with a 3-day history of high fever (up to 40°C) which resolved spontaneously this morning. Shortly after the fever broke, a maculopapular rash appeared on his trunk and neck, sparing the face. The infant appears otherwise well and active. Physical examination reveals no other significant findings apart from the rash. Which of the following viruses is the most likely causative agent?
Examiner's Design Intent
The NBME designed this question to test a student's precise knowledge of the classic clinical presentation of roseola infantum and their ability to differentiate it from other common childhood viral exanthems based on sp…
An 82-year-old man presents with a painful, blistering rash distributed in a band-like pattern on the left side of his chest, stopping abruptly at the midline. He had chickenpox as a child. Physical examination reveals vesicles and crusted lesions following the T4 dermatome. Which of the following best describes the underlying mechanism for this patient's current condition?
Examiner's Design Intent
The NBME designed this question to assess a student's ability to recognize the classic clinical presentation of herpes zoster (shingles) and understand its underlying viral pathogenesis, specifically VZV reactivation fro…
A 24-year-old man presents to the clinic with recurrent painful vesicular lesions on his lips. He states these outbreaks typically occur during periods of stress. Physical examination reveals clusters of vesicles on an erythematous base at the vermillion border of the upper lip. The lesions are consistent with herpes labialis. Which of the following best describes the mechanism of action of the most appropriate antiviral medication for this condition?
Examiner's Design Intent
The NBME designed this question to assess a student's precise knowledge of the mechanism of action of a common, high-yield antiviral drug (acyclovir) for a frequently encountered clinical condition (herpes labialis). It …
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