SGrade/USMLE Step 1/Neuroscience & Neuroanatomy
Neuroscience & Neuroanatomy Practice Questions
Stroke syndromes, herniation, MS and demyelination, brain tumors, dementia and movement disorders, seizures, GBS/MG, cord syndromes, and raised ICP.
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A 38-year-old woman presents with headache, nausea, and transient visual obscurations. Funduscopic examination reveals bilateral blurring of optic disc margins, loss of the optic cup, and retinal venous pulsations are absent. Her neurological examination is otherwise normal. Which of the following findings is most consistent with the funduscopic observations?
Examiner's Design Intent
The NBME designed this question to test the recognition of classic papilledema based on specific funduscopic findings and associated systemic symptoms, requiring differentiation from other optic nerve pathologies. It ass…
A 78-year-old woman presents with progressive memory loss, difficulty with executive functions, and spatial disorientation over 5 years. Her family reports she often gets lost in familiar places and forgets recent events. Neurological examination shows no focal deficits. Which of the following neurotransmitter systems is most significantly affected early in the course of this disease?
Examiner's Design Intent
The NBME designed this question to test the student's foundational knowledge of the primary neurotransmitter pathology in early Alzheimer's disease, a very common and high-yield neurodegenerative disorder. It assesses th…
A 55-year-old woman presents with chronic headaches and gradual weakness in her right leg. Magnetic resonance imaging (MRI) of the brain shows a well-circumscribed, dural-based mass in the left parasagittal region, which appears to have calcifications on imaging. Biopsy of this mass would most likely reveal cells originating from which of the following?
Examiner's Design Intent
The NBME designed this question to assess a student's ability to integrate clinical presentation (headaches, weakness), neuroimaging findings (dural-based mass, calcifications, parasagittal), and basic science knowledge …
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