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SGrade/USMLE Step 1/Antimicrobials

Step 1 · 25 questions

Antimicrobials Practice Questions

Cell wall and protein synthesis inhibitors, fluoroquinolones, antifungal classes, RIPE, malaria and helminths, and HIV ART with toxicities.

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Sample questions

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Question 1Foundation

A 68-year-old man with community-acquired pneumonia is prescribed levofloxacin. Levofloxacin exerts its bactericidal effects primarily by inhibiting which of the following bacterial enzymes?

ADNA gyrase and topoisomerase IV
BPeptidoglycan transpeptidase
CDihydropteroate synthase
DRNA polymerase

Examiner's Design Intent

To assess the student's ability to recall the specific molecular target of a common antibiotic (levofloxacin) and differentiate it from the targets of other major antibiotic classes.

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Question 2Foundation

A 65-year-old neutropenic patient with disseminated candidiasis is started on caspofungin. Caspofungin exerts its fungicidal activity by inhibiting the synthesis of which of the following fungal cell wall components?

AErgosterol
BGlucan
CChitin
DPeptidoglycan

Examiner's Design Intent

To assess the student's knowledge of the specific mechanism of action of echinocandin antifungals, differentiating them from other classes of antifungals targeting different fungal components.

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Question 3Foundation

A 55-year-old man hospitalized with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is initiated on intravenous vancomycin. Vancomycin achieves its bactericidal effect by inhibiting which of the following processes?

ATranspeptidation of peptidoglycan
BTransglycosylation of peptidoglycan
CSynthesis of bacterial folic acid
DFormation of peptide bonds on the 50S ribosomal subunit

Examiner's Design Intent

To assess the student's understanding of the precise molecular mechanism of vancomycin, differentiating it from other cell wall synthesis inhibitors and other classes of antibiotics. It tests the ability to recall specif

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More Step 1 topics

Physiology — Core ConceptsCardiovascular SystemPulmonary SystemRenal SystemEndocrine SystemAnatomy — Core Concepts
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