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SGrade/USMLE Step 1/Autonomic & CNS Pharmacology

Step 1 · 25 questions

Autonomic & CNS Pharmacology Practice Questions

Autonomic agonists/antagonists, anticholinesterases, psychopharmacology, mood stabilizers, benzodiazepines, CNS stimulants, opioids, and local/general anesthetics.

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Sample questions

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Question 1Foundation

A 45-year-old man undergoing a colonoscopy is administered an intravenous anesthetic. He rapidly loses consciousness, and his respiration becomes shallow. He awakens quickly after the procedure with no residual effects. During the procedure, his blood pressure decreased transiently. Which of the following intravenous anesthetics was most likely used?

AKetamine
BEtomidate
CPropofol
DMidazolam

Examiner's Design Intent

To assess the student's ability to differentiate between common intravenous anesthetic agents based on their characteristic clinical effects, particularly hemodynamic stability and recovery profile, in a procedural conte

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Question 2Foundation

A 32-year-old woman presents to the clinic with persistent nasal congestion that has not improved with saline sprays. She reports frequently using an over-the-counter nasal decongestant spray for the past two weeks, several times a day. Examination reveals significant erythema and edema of the nasal mucosa. Her blood pressure is 120/70 mmHg, and heart rate is 75 bpm. The active ingredient in the nasal spray she is using primarily acts on which of the following adrenergic receptors?

ABeta-1 adrenergic receptors
BBeta-2 adrenergic receptors
CAlpha-1 adrenergic receptors
DDopamine-1 receptors

Examiner's Design Intent

To assess the student's ability to connect a common clinical presentation (nasal congestion) and a readily available medication class (nasal decongestant) to the specific underlying autonomic pharmacology, particularly t

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Question 3Foundation

A 28-year-old woman is diagnosed with generalized anxiety disorder. She reports experiencing constant worry, muscle tension, and difficulty concentrating for several months. She is concerned about potential sedation and dependence with anxiolytic medications due to her professional responsibilities. Which of the following medications would be the most appropriate initial treatment choice for this patient?

AAlprazolam
BBuspirone
CLorazepam
DClonazepam

Examiner's Design Intent

To assess the student's ability to differentiate between medications for acute vs. chronic anxiety management and to prioritize patient-specific concerns (sedation, dependence) when selecting pharmacotherapy for Generali

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More Step 1 topics

Physiology — Core ConceptsCardiovascular SystemPulmonary SystemRenal SystemEndocrine SystemAnatomy — Core Concepts
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